Melissa White Memorial Laboratory

Melissa White Memorial Laboratory

Research in The Melissa White Memorial Laboratory strives to understand the underlying biological principles of resistance to therapy, to evaluate the usefulness and clinical relevance of novel targeted therapies and to develop tests to identify poor responders at diagnosis, so that therapy can be altered accordingly.

While tyosine kinase inhibitor(TKI) therapy has revolutionized the treatment of CML, an important focus of our laboratory is to identify patients at risk of responding poorly to therapy due to TKI resistance, so that at diagnosis therapy can be tailored for the best possible clinical outcome. Coupled with our world-class clinical trials and translational research, our laboratory heads pioneered training programs that see at least 6 international haematologists trained in the latest techniques for management and monitoring of leukaemia. Taken together the work from our laboratory produces seminal findings in leukaemia research and contributes to the always changing clinical management of adult and childhood leukaemia.