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Tissue Architecture and Organ Function Laboratory

Tissue Architecture and Organ Function Laboratory


“Patient-derived glioblastoma organoid model imaging using live confocal imaging. Red: tumour cells; Gray: Non-malignant cells. Image generated by Dr. Mariana Oksdath Mansilla.”

The Tissue Architecture and Organ Function Laboratory was founded in 2017 and headed since then by Dr Guillermo Gomez.

Its main research focus is on Brain Cancer, specifically on the role of the tumour microenvironment and interactions between tumour cells and stromal cells on glioblastoma growth and invasion.

For this we have developed cutting-edge wet-lab, imaging and computational approaches, including artificial intelligence (AI), for the study of fresh tumour samples from patients using multimodal analysis of tissue sections and the growth of patient-derived brain tumour organoids.

These fundamental advances now allow us to:

  • Interrogate and access information directly from the patient's tumour.
  • Perform Functional experiments in better and clinically relevant in vitro models for brain cancer.

Together, these technologies enable us to functional evaluate molecular targets and biomarkers during the preclinical stage for their future translation into clinical trials.

POSITIONS OPEN:
Positions for PhD and Honor’s students are open in this laboratory. Prospective postdocs please contact Guillermo Gomez if you are interested in joining his lab even if you are in your final year of a PhD.

Enquires from candidates with a strong background in (any of) the following areas: Cell and tissue biology, computer science, artificial intelligence, stem cell research, immunology, bioinformatics and mechanobiology are very welcome. Positions may be dependent on the time of the year and funding. 

SELECTED PUBLICATIONS

  1. Lenin S, …, Gomez GA*. A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma. International Journal of Molecular Sciences. 2021, 22, 4322. *Corresponding author.

  2. Zadeh Shirazi A*, …, Gomez GA*. A deep convolutional neural network for segmentation of whole-slide pathology images identifies novel tumour cell-perivascular niche interactions that are associated with poor survival in glioblastoma. British Journal of Cancer. *Corresponding authors.

  3. Oksdath Mansilla M*, …, Pitson SM, Brown MP, Ebert LM, Gomez GA*. 3D-printed microplate inserts for long term high-resolution imaging of live brain organoids. BMC Biomedical Engineering. *Corresponding authors.

  4. Zadeh Shirazi A*, Fornaciari E, McDonnell MD, Yaghoobi M, Cevallos Y, Tello-Oquendo L, Inca D, Gomez GA*. The Application of Deep Convolutional Neural Networks to Brain Cancer Images: A Survey. Journal of Personalized Medicine. 2020; 2020,10(4), 224 (doi.org/10.3390/jpm10040224). *Corresponding authors.

  5. Zadeh Shirazi A*, …, Gomez GA*. DeepSurvNet: deep survival convolutional network for brain cancer survival rate classification based on histopathological images. Medical & Biological Engineering and Computing. 2020; 58(5):1031-1045. (doi:10.1007/s11517-020-02147-3). *Corresponding authors.

  6. Gomez GA, Oksdath M, Brown MP, Ebert LM. 2019. New approaches to model glioblastoma in vitro using brain organoids: implications for precision oncology. Translational Cancer Research (doi: 10.21037/tcr.2019.09.08).

  7. Perrin SL, Samuel MS, Koszyca B, Brown MP, Ebert LM*, Oksdath M*, Gomez GA*. 2019. Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments. Biochem Soc Trans. Mar 22. pii: BST20180444.. *Corresponding authors.

  8. Priya R, Gomez GA*, Budnar S, Verma S, Cox HL, Hamilton NA, Yap AS*. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin  junctions. Nature Cell Biology2015Oct;17(10):1282-93. *Corresponding authors.

  9. Caldwell BJ, Lucas C, Kee AJ, Gaus K, Gunning PW, Hardeman EC, Yap AS* and Gomez GA*. Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens. Cytoskeleton2014; 71:663. *Corresponding authors.

  10. Wu SK, Gomez GA*, Yap AS*, et. al. Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia. Nature Cell Biology. 2014 Feb;16(2):167. *Corresponding authors.

  11. Ratheesh A.*, Gomez GA*, Priya R, Verma S, Kovacs EM, Jiang K, Brown NH, Akhmanova A, Stehbens SJ, Yap AS. Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.Nature Cell Biology.2012 14(8):818-28. * co-first authors.