Vascular Biology and Cell Trafficking Laboratory
Research Program Overview:
Blood vessels form an extensive network that transports cells, oxygen and nutrients throughout all tissues and organs. Blood vessels are key components in our fight against disease and improved understanding of endothelial cells (ECs, specialised cells which form the inner lining of blood vessels), will provide new knowledge and novel treatment options for many fatal diseases, including cancer, heart disease and diabetes.
We have leading research in, vasculogenic mimicry (VM), a process wherein cancer cells themselves form vascular-like structures to increase access to the blood supply to assist in tumour growth. In the most aggressive and difficult to treat cancers of the breast, skin and pancreas, increased VM is associated with poor clinical outcome. We have begun to identify novel elements in VM and are now targeting these with an overall aim to provide better outcomes for cancer patients.
We also have patented technology on making medical devices ‘bioinvisible’. For example, vascular occlusions are a major contributor to cardiovascular disease (CVD) which is a leading cause of death worldwide. Overcoming these occlusions requires insertion of devices (such as stents) to maintain vessel diameter which are seen by the body as foreign. Our innovative concept modifies stents with a patented BIOINVISIBLE low-fouling surface with proven revascularisation of implanted devices requiring minimal intervention and medication. This work is led by Dr Eli Moore (Biocompatible Devices Group).
Current Research Projects:
- Investigating the role of desmoglein-2 in the progression of blood cancers and solid tumours
- Understanding the contribution of vasculogenic mimicry in the tumour microenvironment and cancer progression
- Defining the gene expression, signalling pathways and spatial proteomics that promote and modulate vasculogenic mimicry and anti-tumour immunity
- Advancing bioinvisible technology to improve implantable medical devices (TekCyte)
- Advancing CAR-T cells for application to combat solid tumours (Carina Biotech)
Select Recent Publications:
- Tan LY, Cockshell MP, Moore E, Myo Min KK, Ortiz M, Johan MZ, Ebert BW, Ruszkiewicz A, Brown MP, Ebert LM*, Bonder CS*.
Vasculogenic mimicry structures in melanoma support the recruitment of monocytes.
OncoImmunology, 11(1):2043673, 2022. *equal senior authors
- Burzava A, Jasieniak M, Cockshell MP, Voelcker NH, Bonder CS, Griesser HJ, Moore E.
Attachment of endothelial colony-forming cells onto a surface bearing immobilized anti-CD34 antibodies: specific CD34 binding versus nonspecific binding.
Biointerphases, 17(3):031003, 2022.
- Ebert LM, Vandyke K, Johan MZ, DeNichilo M, Tan LY, Myo Min KK, Weimann BM, Ebert BW, Pitson SM, Zannettino ACW, Wallington-Beddoe CT, Bonder CS.
Desmoglein-2 expression by multiple myeloma is an independent predictor of poor prognosis.
Molecular Oncology, Jul 10 2021. doi: 10.1002/1878-0261.13055
- Flemming J, Hill B, Haque M, Raad J, Bonder CS, Harshyne L, Rodeck U, Luginbuhl A, Wahl J, Tsai K, Wermuth P, Overmiller A, Mahoney MG.
miRNA- and Cytokine-associated Extracellular Vesicles Mediate Squamous Cell Carcinoma
Journal of Extracellular Vesicles, 9(1):1790159, 2020
- Martini C, Thompson EJ, Hyslop S, Cockshell M, Dale B, Ebert LM, Woods A, Josefsson EC, Bonder CS
Platelets disrupt vasculogenic mimicry by cancer cells
Scientific Reports, 10(1):5869. doi: 10.1038/s41598-020-62648-x, 2020
- Neubauer H, Tea M., Powell J, Pitman M, Moretti P, Gliddon B, Day B, Stringer B, Davies L, Stefanidis C, Kular J, Samuel M, Bonder CS, Pitson SM.
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
Oncogene, doi: 10.1038/s41388-018-0504-9, 2018.
- Tan LY, Mintoff C, Johan MZ, Ebert BW, Fedele C, Zhang YF, Szeto P, Sheppard KE, McArthur GA, Foster-Smith E, Ruszkiewicz A, Brown MP, Bonder CS*, Shackleton M*, Ebert LM*.
Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome.
Oncotarget, 7(29):46492-46508, 2016. * equal senior authors.
- Ebert LM, Tan LY, Johan MZ, Myo Min KK, Cockshell MP, Parham KA, Betterman K, Szeto P, Boyle S, Silva L, Peng A, Zhang Y, Ruszkiewicz A, Zannettino ACW, Gronthos S, Koblar S, Harvey NL, Lopez AF, Shackleton M, Bonder CS.
A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis.
Angiogenesis, 19(4):463-68, 2016.
- Parham K, Zebol J, Tooley K, Sun WY, Moldenhauer L, Cockshell M, Gliddon B, Moretti P, Tigyi G, Pitson S, Bonder CS
Sphingosine 1-phosphate is a ligand for PPARg which regulates neoangiogenesis
FASEB J, 29(9):3638-53, 2015.
- Penko D, Rojas-Canales D, Peiris H, Sun WY, Drogemuller C, Coates PTH, Bonder CS, Jessup CJ
Endothelial progenitor cells enhance islet engraftment, influence beta cell function and modulate connexin 36 expression
Cell Transplantation, 24(1):37-48, 2015.
Read a complete list of publications