Cells are constantly exposed to several internal (metabolites, damaged macromolecules such as proteins and lipids) and external stimuli (e.g. microbes, radiations, temperature and chemicals) which stress the cells. A successful survival of an organism depends on how well it adapts to different stress. Cells survive these insults by mounting specific repair mechanisms such as oxidative stress response, unfolded protein response (UPR), and DNA damage response (DDR) which aid in regaining normal physiology. When they fail to restore homeostasis, they undergo cell death or they survive in a maladaptive phase resulting in pathologies such as malignancies, neurodegenerative, cardiovascular, and metabolic disorders. In our lab we investigate the function of these stress responses in innate immune defences, in the context of pathologies such as cancer and infection which will help in understanding disease pathogenesis and present novel targets for therapeutic treatments.