The Molecular Regulation Laboratory is dedicated to exploring molecular basis of organismal homeostasis through the essential cellular processes such as ubiquitination and cell death. Given the discovery nature of our research program our work influences many areas of pathophysiology. Over the years we have made pioneering contributions to biomedical research. For example, our team discovered one of the first mammalian cell death proteases (caspase-2), identified and characterized key components of the cell death machinery, demonstrated how cell death is regulated by caspases, and described the developmental cell death modality that requires autophagy. We also discovered one of the first and evolutionarily most conserved family of ubiquitin ligases (the NEDD4 family), identified a ubiquitin-like protein NEDD8 that led to the discovery of protein modification pathway now known as Neddylation, and identified NDFIP1 and NDFIP2 as adaptors/regulators of NEDD4 family members. Much of the work in our laboratory is based on our own discoveries as we continue to explore the molecular mechanisms, regulation and physiological functions of cell death and ubiquitination, and how their dysregulation results in a multitude of diseases, including cancer, inflammation and kidney injury.
Loretta Dorstyn (Hons, PhD, Postdoc) (Current Project Leader)
Natasha Harvey (PhD, Postdoc)
Alison Butt (Postdoc)
Kieran Harvey (Hons, PhD)
Corina Jolliffe (Research Staff)
Gayathri Parasivam (Research Staff)
Paul Colussi (Postdoc)
Linda Shearwin-Whyatt (Postdoc)
Stuart Read (Research Staff, Postdoc)
Bryan Haines (Postdoc)
Kathryn Mills (Research Staff)
Tasman Daish (PhD, Postdoc)
Joanna Doumanis (PhD)
Zoe Kilpatrick (Hons)
Lucianne Vandaleur (Research Staff)
Belinda Baliga (Research Staff)
Andrew Fotia (PhD)
Dinali Devasagayam (Research Staff)
Dimitrios Cakouros (Postdoc)
Brian Degger (Postdoc)
Hazel Dalton (Postdoc)
Ingrid Lensink (Postdoc)
Lidia Lambrusco (Research Staff)
Jantina Manning (PhD, Postdoc) (Current Project Leader)
Alex Saxon (Hons)
Joel Castro (Postdoc)
Lien Ha Ho (Postdoc)
Balazs Bajka (Postdoc)
Robyn Taylor (Research Staff)
Alicia Paterson (Research Staff)
Nirmal Lorensuhewa (Postdoc)
Daniel Iachini (Research Staff)
Alyshea Collaco (Research Staff)
May Aung-Htut (Postdoc)
Wenying Zhu (Hons)
Scott Townley (Research Staff)
Yew Ann Leong (Research Staff)
Natalie Foot (Postdoc)
Kristen Ho (Research Staff)
Josephine Wright (Research Staff)
Zoe Campbell (Research Staff)
Sarah To (Research Staff)
Joey Puccini (Hons, PhD, Postdoc)
Tianqi Xu (Hon, PhD, Postdoc)
Kathryn Adriaanse (Hons)
Pranay Goel (PhD)
Kimberley Mackenzie (Postdoc)
Natasha Boase (Postdoc)
Sonia Shalini (Postdoc) (Current Project Leader)
Saman Ibrrahimi (Postdoc)
Eareanee Niedzwiecki (Research Staff)
Claire Wilson (Postdoc)
Andrej Nikolic (Research Staff)
Lukas Peinter (Visiting PhD)
Omri Alfassy (Research Staff)
Nikolina Sladojevic (Research Staff)
Swati Dawar (PhD)
Tanya Henshall (Postdoc)
Sonia Dayan (Research Staff)
Ambika Murthy (Postdoc)
Xin Jiang (Hons)
Ryan Norton (Hons)
Erica Kolze (Hons)
Kelly Gembus (Research Staff)
Ammara Farooq (PhD)
Shannon Nicolson (PhD)
Julian Carosi (PhD)
Donna Denton (Postdoc)
James Cooper (MBiotech)
Thuy Tien Ngyuen (MBiotech)
Dylan De Bellis (Research Staff)
Jack Scanlan (Hons)
Michael Katschner (MPhil)