The Tissue Architecture and Organ Function Laboratory was founded in 2017 and has been led by Dr Guillermo Gomez since then.
Our primary research focus is on BRAIN CANCER, specifically GLIOBLASTOMA. We investigate the role of the tumour microenvironment and interactions between tumour cells and stromal cells on glioblastoma growth, invasion and resistance to therapy. Our goal is to discover, develop and translate new personalised treatments for patients affected by this terrible and aggressive type of brain cancer.
For this, we pioneered novel approaches to study the complexity of highly heterogenous brain tumours, like glioblastoma using artificial intelligence and patient-derived glioblastoma explant organoids (GBOs).
The access to patient-derived primary tissue, through our collaboration with the SA Neurological Tumour bank and Adelaide public hospitals, and matched patient-derived GBOs provide us with the opportunity to deeply characterise these samples using a variety of cutting-edge technologies. These include single-cell RNA sequencing (scRNAseq), spatial-metabolomics/transcriptomics/proteomics, atomic force microscopy (AFM), advanced bioinformatics.
We integrate this multidimensional data with cutting-edge artificial intelligence (AI) and patients demographical information to provide novel ways to identify
We therefore are taking advantage of these fundamental technological advances to (i) interrogate and access information directly from the patient's tumour and (ii) perform functional experiments in better and clinically relevant in vitro models for brain cancer. Our research pipeline provide a novel approach for the identification and pre-clinical functional validation of new molecular targets and biomarkers for their future translation into clinical trials.
Our goal is to find new personalised treatments that increase survival and improve the quality of life for every brain cancer patient.